Notch signaling plays a key role in cardiac cell differentiation

  title={Notch signaling plays a key role in cardiac cell differentiation},
  author={Mary D. L. Chau and Richard A. Tuft and Kevin Fogarty and Zheng-Zheng Bao},
  journal={Mechanisms of Development},
Results from lineage tracing studies indicate that precursor cells in the ventricles give rise to both cardiac muscle and conduction cells. Cardiac conduction cells are specialized cells responsible for orchestrating the rhythmic contractions of the heart. Here, we show that Notch signaling plays an important role in the differentiation of cardiac muscle and conduction cell lineages in the ventricles. Notch1 expression coincides with a conduction marker, HNK-1, at early stages. Misexpression of… CONTINUE READING


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