Notch signaling modulates the activation of microglial cells.

@article{Grandbarbe2007NotchSM,
  title={Notch signaling modulates the activation of microglial cells.},
  author={Luc Grandbarbe and Alessandro Michelucci and Tony Heurtaux and Karin Hemmer and Eleonora Morga and Paul Heuschling},
  journal={Glia},
  year={2007},
  volume={55 15},
  pages={1519-30}
}
The Notch signaling pathway plays a crucial role in specifying cellular fate in metazoan development by regulating communication between adjacent cells. Correlative studies suggested an involvement of Notch in hematopoietic cell development. Here, we report that the Notch pathway is expressed and active in microglial cells. During inflammatory activation, the transcription of the Notch down-stream effector Hes1 is downregulated. When Notch1 transcription in microglia is inhibited, an… CONTINUE READING
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