Notch signaling is not essential in sonic hedgehog-activated medulloblastoma

  title={Notch signaling is not essential in sonic hedgehog-activated medulloblastoma},
  author={Beryl A. Hatton and Elisabeth H. Villavicencio and John Pritchard and Mathias Leblanc and Stacey J. Hansen and Magda Ulrich and Sally H. Ditzler and Barbara J. Pullar and Mark R. Stroud and James M. Olson},
Dysregulated signal transduction through the notch pathway has been noted in human and mouse medulloblastoma studies. Gamma secretase inhibitors (GSIs) impair notch signaling by preventing the cleavage of transmembrane notch proteins into their active intracellular domain fragments. Previous studies have shown that GSI treatment caused apoptosis and impaired medulloblastoma cell engraftment in xenograft systems. In this study, we used in vivo genetic and pharmacologic approaches to quantify the… CONTINUE READING


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The origins of medulloblastoma subtypes.

Annual review of pathology • 2008
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