Notch signaling induces cell cycle arrest in small cell lung cancer cells.

Abstract

Among the various forms of human lung cancer, small cell lung cancer (SCLC) exhibits a characteristic neuroendocrine (NE) phenotype. Neural and NE differentiation in SCLC depend, in part, on the action of the basic-helix-loop-helix (bHLH) transcription factor human achaete-scute homologue-1 (hASH1). In nervous system development, the Notch signaling pathway… (More)

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@article{Sriuranpong2001NotchSI, title={Notch signaling induces cell cycle arrest in small cell lung cancer cells.}, author={Viroj Sriuranpong and Melania Borges and R. Ravi and Daniel Arnold and Barry D. Nelkin and Steve Baylin and Douglas W. Ball}, journal={Cancer research}, year={2001}, volume={61 7}, pages={3200-5} }