Notch signaling in vascular development.

  title={Notch signaling in vascular development.},
  author={Tatsuya Iso and Yasuo Hamamori and L. Kedes},
  journal={Arteriosclerosis, thrombosis, and vascular biology},
  volume={23 4},
Notch signaling is an extremely conserved and widely used mechanism regulating cell fate in metazoans. Interaction of Notch receptors (Notch) with their ligands (Delta-like or Jagged) leads to cleavage of the Notch intracellular domain (NICD) that migrates into the nucleus. In the nucleus, NICD associates with a transcription factor, RBP-Jk. The NICD-RBP-Jk complex, in turn, upregulates expression of primary target genes of Notch signaling, such as hairy and enhancer of split (HES) and HES… CONTINUE READING


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