Notch signaling in normal and disease States: possible therapies related to glycosylation.

@article{Rampal2007NotchSI,
  title={Notch signaling in normal and disease States: possible therapies related to glycosylation.},
  author={Raajit K Rampal and Kelvin B. Luther and Robert S. Haltiwanger},
  journal={Current molecular medicine},
  year={2007},
  volume={7 4},
  pages={427-45}
}
The Notch signaling pathway is involved in a wide variety of highly conserved developmental processes in mammals. Importantly, mutations of the Notch protein and components of its signaling pathway have been implicated in an array of human diseases (T-cell leukemia and other cancers, Multiple Sclerosis, CADASIL, Alagille Syndrome, Spondylocostal Dysostosis). In mammals, Notch becomes activated upon binding of its extracellular domain to ligands (Delta and Jagged/Serrate) that are present on the… CONTINUE READING

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