Notch signaling enhances nestin expression in gliomas.

@article{Shih2006NotchSE,
  title={Notch signaling enhances nestin expression in gliomas.},
  author={Alan H. Shih and Eric C. Holland},
  journal={Neoplasia},
  year={2006},
  volume={8 12},
  pages={1072-82}
}
Recent findings suggest that Notch signaling is active in brain tumors and stem cells, and that stem cells or cells with progenitor characteristics contribute to brain tumor formation. These stem cells are marked by expression of several markers, including nestin, an intermediate filament protein. We have studied how the Notch signaling pathway affects nestin expression in brain tumors. We find that Notch receptors and ligands are expressed in vitro and in human samples of glioblastomas, the… CONTINUE READING
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