Notch signaling directly controls cell proliferation in the Drosophila wing disc.

@article{Baonza2000NotchSD,
  title={Notch signaling directly controls cell proliferation in the Drosophila wing disc.},
  author={Antonio Baonza and Antonio Garcı́a-Bellido},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={2000},
  volume={97 6},
  pages={
          2609-14
        }
}
Notch signaling is involved in cell differentiation and patterning during morphogenesis. In the Drosophila wing, Notch activity regulates the expression of several genes at the dorsal/ventral boundary, and this is thought to elicit wing-cell proliferation. In this work, we show the effect of clones of cells expressing different forms of several members of the Notch signaling pathway, which result in an alteration of Notch activity. The ectopic expression in clones of activated forms of Notch or… CONTINUE READING

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