Notch signaling controls proliferation through cell-autonomous and non-autonomous mechanisms in the Drosophila eye.

@article{ReynoldsKenneally2005NotchSC,
  title={Notch signaling controls proliferation through cell-autonomous and non-autonomous mechanisms in the Drosophila eye.},
  author={Jessica Reynolds-Kenneally and Marek Mlodzik},
  journal={Developmental biology},
  year={2005},
  volume={285 1},
  pages={38-48}
}
During Drosophila eye development, localized Notch signaling at the dorsal ventral (DV)-midline promotes growth of the entire eye field. This long-range action of Notch signaling may be mediated through the diffusible ligand of the Jak/STAT pathway, Unpaired (Upd), which was recently identified as a downstream target of Notch. However, Notch activity has not been shown to be cell-autonomously required for Upd expression and therefore yet another diffusible signal may be required for Notch… CONTINUE READING

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