Notch signaling contributes to proliferation and tumor formation of human T-cell leukemia virus type 1-associated adult T-cell leukemia.

@article{Pancewicz2010NotchSC,
  title={Notch signaling contributes to proliferation and tumor formation of human T-cell leukemia virus type 1-associated adult T-cell leukemia.},
  author={Joanna Pancewicz and John M. Taylor and Abhik Datta and Hicham Hachem Baydoun and Thomas A. Waldmann and Olivier Hermine and Christophe Nicot},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={2010},
  volume={107 38},
  pages={16619-24}
}
The Notch signaling pathway plays an important role in cellular proliferation, differentiation, and apoptosis. Unregulated activation of Notch signaling can result in excessive cellular proliferation and cancer. Human T-cell leukemia virus type 1 (HTLV-I) is the etiological agent of adult T-cell leukemia (ATL). The disease has a dismal prognosis and is invariably fatal. In this study, we report a high frequency of constitutively activated Notch in ATL patients. We found activating mutations in… CONTINUE READING