Notch signaling and cardiac repair.

  title={Notch signaling and cardiac repair.},
  author={Natalie A. Gude and Mark Sussman},
  journal={Journal of molecular and cellular cardiology},
  volume={52 6},
Notch signaling is critical for proper heart development and recently has been reported to participate in adult cardiac repair. Notch resides at the cell surface as a single pass transmembrane receptor, transits through the cytoplasm following activation, and acts as a transcription factor upon entering the nucleus. This dynamic and widespread cellular distribution allows for potential interactions with many signaling and binding partners. Notch displays temporal as well as spatial versatility… CONTINUE READING
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