Notch signaling: cell fate control and signal integration in development.

  title={Notch signaling: cell fate control and signal integration in development.},
  author={Spyros Artavanis-Tsakonas and Matthew D. Rand and Robert J. Lake},
  volume={284 5415},
Notch signaling defines an evolutionarily ancient cell interaction mechanism, which plays a fundamental role in metazoan development. Signals exchanged between neighboring cells through the Notch receptor can amplify and consolidate molecular differences, which eventually dictate cell fates. Thus, Notch signals control how cells respond to intrinsic or extrinsic developmental cues that are necessary to unfold specific developmental programs. Notch activity affects the implementation of… 

Notch signaling and the determination of appendage identity.

It is shown that Notch signaling regulates the expression of the master control genes eyeless, vestigial, and Distal-less, which in combination with homeotic genes induce the formation of eyes, wings, antennae, and legs in Drosophila.

The Notch signaling pathway: molecular basis of cell context dependency.

Notch signals control the fate of immature progenitor cells in the intestine

By modulating Notch activity in the mouse intestine, this work directly implicates Notch signals in intestinal cell lineage specification and shows that Notch activation is capable of amplifying the intestinal progenitor pool while inhibiting cell differentiation.

Variations on the Notch pathway in neural development

Notch signaling in lymphopoiesis.

Paradigms of Notch Signaling in Mammals

This review discusses the origin of postulated Notch functions, gives examples from different mammalian organ systems, and tries to relate them to the hematopoietic system.

Notch signalling: sensor and instructor of the microenvironment to coordinate cell fate and organ morphogenesis.

Notch signaling in T cell development.




Delta-notch signaling and Drosophila cell fate choice.

Emerging evidence regarding the expression and function of Delta and Notch during development also raise possible alternatives to the currently favored hypothesis that Delta-Notch interactions generate instructive signals that mediate a process termed lateral inhibition.

Notch signalling in Drosophila: three ways to use a pathway.

  • S. Bray
  • Biology
    Seminars in cell & developmental biology
  • 1998
These illustrations illustrate how the activity of the Notch signalling pathway can be modulated both at the cell surface, through availability and effectiveness of ligand interactions, and inside the cell, through effects on the transduction pathway and the responsiveness of target genes.

Notch signaling: direct or what?

  • G. Weinmaster
  • Biology
    Current opinion in genetics & development
  • 1998

Notch signaling : Signal transduction

The Notch/Lin-12/Glp-1 receptor family mediates the specification of numerous cell fates during development in Drosophila and Caenorhabditis elegans and putative components of the signaling cascade are identified, including a conserved family of extracellular ligands and two cellular factors that may associate with the Notch Intracellular domain.

Delta and Serrate are redundant Notch ligands required for asymmetric cell divisions within the Drosophila sensory organ lineage.

Asymmetric divisions allow a precursor to produce four distinct cells of a Drosophila sensory organ lineage (SOL). Whereas this process requires cell-cell communication via Notch (N) receptor,

Interactions between Wingless and Notch during the assignment of cell fates in Drosophila.

The possibility that Wingless acts as a ligand for Notch as part of a switch that is iteratively involved in the assignation of cell fates during development is discussed.

Interaction Between Wingless and Notch Signaling Pathways Mediated by Dishevelled

It is proposed that Dishevelled, in addition to transducing the Wingless signal, blocks Notch signaling directly, thus providing a molecular mechanism for the inhibitory cross talk observed between these pathways.

Suppressor of Hairless-independent events in Notch signaling imply novel pathway elements.

In vivo expression of the Notch ANK repeats reveals a cell non-autonomous effect and elicits mutant phenotypes that indicate the existence of novel downstream events in Notch signaling.

Complex cellular and subcellular regulation of notch expression during embryonic and imaginal development of Drosophila: implications for notch function

It is found that Notch is expressed in a tissue- specific manner as early as the cellular blastoderm stage, when cells of the presumptive mesoderm clearly express less Notch than adjacent ectodermal precursors.