Notch signal protects non-parenchymal cells from ischemia/reperfusion injury in vitro by repressing ROS.

Abstract

BACKGROUND We have previously reported that Notch signaling pathway protects hepatocytes from ischemia/ reperfusion (I/R) injury by repressing reactive oxygen species (ROS) production. However, apart from hepatocytes, non-parenchymal cells including vascular endothelia cells, Kupffer cells and hepatic stellate cells are also reported to be involved in… (More)

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