Notch reporter activity in breast cancer cell lines identifies a subset of cells with stem cell activity.

@article{DAngelo2015NotchRA,
  title={Notch reporter activity in breast cancer cell lines identifies a subset of cells with stem cell activity.},
  author={Rosemarie Chirco D'Angelo and Maria Ouzounova and April Davis and Daejin Choi and Stevie M. Tchuenkam and Gwangil Kim and Tahra K. Luther and Ahmed A. Quraishi and Yasin Şenbabaoğlu and Sarah J. Conley and Shawn G. Clouthier and Khaled Atya Hassan and Max S. Wicha and Hasan Korkaya},
  journal={Molecular cancer therapeutics},
  year={2015},
  volume={14 3},
  pages={
          779-787
        }
}
Developmental pathways such as Notch play a pivotal role in tissue-specific stem cell self-renewal as well as in tumor development. However, the role of Notch signaling in breast cancer stem cells (CSC) remains to be determined. We utilized a lentiviral Notch reporter system to identify a subset of cells with a higher Notch activity (Notch(+)) or reduced activity (Notch(-)) in multiple breast cancer cell lines. Using in vitro and mouse xenotransplantation assays, we investigated the role of the… CONTINUE READING
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