Notch regulates the generation of diverse cell types from the lateral lineage of Drosophila antennal lobe.

@article{Das2010NotchRT,
  title={Notch regulates the generation of diverse cell types from the lateral lineage of Drosophila antennal lobe.},
  author={Abhijit Das and Heinrich Reichert and Ver{\^o}nica Pinto Rodrigues},
  journal={Journal of neurogenetics},
  year={2010},
  volume={24 1},
  pages={42-53}
}
Diverse neuronal cell types arise from the lateral neuroblast in the antennal lobe of Drosophila. The authors show that loss of Notch function from the entire lineage during development leads to an absence of local interneurons (LNs) with a concomitant increase in the number of projection neurons (PNs). The presence of the intracellular domain of Notch was observed within the nucleus of newly born neurons within the neuroblast lineage. This leads to the suggestion that Notch acts in a binary… CONTINUE READING