Notch pathway inhibition controls myeloma bone disease in the murine MOPC315.BM model

@inproceedings{Nickel2014NotchPI,
  title={Notch pathway inhibition controls myeloma bone disease in the murine MOPC315.BM model},
  author={Nils P. Nickel and J Godau and Bettina M Willie and Georg N. Duda and Ralf Schwarzer and B Cirovic and Achim Leutz and Rudolf A Manz and Bjarne Bogen and Bernd Doerken and Franziska Jundt},
  booktitle={Blood cancer journal},
  year={2014}
}
Despite evidence that deregulated Notch signalling is a master regulator of multiple myeloma (MM) pathogenesis, its contribution to myeloma bone disease remains to be resolved. Notch promotes survival of human MM cells and triggers human osteoclast activity in vitro. Here, we show that inhibition of Notch through the γ-secretase inhibitor XII (GSI XII) induces apoptosis of murine MOPC315.BM myeloma cells with high Notch activity. GSI XII impairs murine osteoclast differentiation of receptor… CONTINUE READING
7 Citations
38 References
Similar Papers

References

Publications referenced by this paper.
Showing 1-10 of 38 references

Similar Papers

Loading similar papers…