Notch oncoproteins depend on gamma-secretase/presenilin activity for processing and function.

Abstract

During normal development Notch receptor signaling is important in regulating numerous cell fate decisions. Mutations that truncate the extracellular domain of Notch receptors can cause aberrant signaling and promote unregulated cell growth. We have examined two types of truncated Notch oncoproteins that arise from proviral insertion into the Notch4 gene… (More)

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@article{Das2004NotchOD, title={Notch oncoproteins depend on gamma-secretase/presenilin activity for processing and function.}, author={Indranil Das and Colleen M Craig and Yasuhiro Funahashi and Kwang-Mook Jung and Tae-wan Kim and Richard Byers and Andrew P. Weng and Jeffery L. Kutok and Jon C Aster and Jan Kitajewski}, journal={The Journal of biological chemistry}, year={2004}, volume={279 29}, pages={30771-80} }