Notch oncoproteins depend on gamma-secretase/presenilin activity for processing and function.

@article{Das2004NotchOD,
  title={Notch oncoproteins depend on gamma-secretase/presenilin activity for processing and function.},
  author={Indranil Das and Colleen M Craig and Yasuhiro Funahashi and K Jung and Tae-wan Kim and Richard Byers and Andrew P. Weng and Jeffery L. Kutok and Jon C Aster and Jan Kitajewski},
  journal={The Journal of biological chemistry},
  year={2004},
  volume={279 29},
  pages={30771-80}
}
During normal development Notch receptor signaling is important in regulating numerous cell fate decisions. Mutations that truncate the extracellular domain of Notch receptors can cause aberrant signaling and promote unregulated cell growth. We have examined two types of truncated Notch oncoproteins that arise from proviral insertion into the Notch4 gene (Notch4/int-3) or a chromosomal translocation involving the Notch1 gene (TAN-1). Both Notch4/int-3 and TAN-1 oncoproteins lack most or all of… CONTINUE READING