Notch ligands potentiate IL-7-driven proliferation and survival of human thymocyte precursors.

Abstract

Notch and IL-7 are both well-characterized factors involved in T-cell development. In contrast to the mouse model, their precise requirements in the differentiation and/or proliferation of various stages of human thymic development have not been fully explored. Here, we demonstrate that IL-7 alone is sufficient to induce the differentiation of ex vivo… (More)
DOI: 10.1002/eji.200838765

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