Notch ligands expressed by follicular dendritic cells protect germinal center B cells from apoptosis.

@article{Yoon2009NotchLE,
  title={Notch ligands expressed by follicular dendritic cells protect germinal center B cells from apoptosis.},
  author={S O Yoon and Xin Zhang and Paul Berner and Bianca Blom and Yong Sung Choi},
  journal={Journal of immunology},
  year={2009},
  volume={183 1},
  pages={352-8}
}
The Notch signaling pathway is one of the most conserved mechanisms to regulate cell fate in many tissues during development and postnatal life. In the immune system, Notch signaling regulates T and B cell development and modulates the differentiation of T and B cells. In this study, we investigated the functional roles of Notch signaling in human B cell differentiation within the germinal center (GC). Notch ligands, Delta-like 1 (Dll1) and Jagged 1 (Jg1), are expressed by follicular dendritic… CONTINUE READING

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