Notch ligand delta-like 4 regulates development and pathogenesis of allergic airway responses by modulating IL-2 production and Th2 immunity.

@article{Jang2010NotchLD,
  title={Notch ligand delta-like 4 regulates development and pathogenesis of allergic airway responses by modulating IL-2 production and Th2 immunity.},
  author={Sihyug Jang and Matthew A. Schaller and Aaron A. Berlin and Nicholas W Lukacs},
  journal={Journal of immunology},
  year={2010},
  volume={185 10},
  pages={5835-44}
}
Activation of the canonical Notch pathways has been implicated in Th cell differentiation, but the role of specific Notch ligands in Th2-mediated allergic airway responses has not been completely elucidated. In this study, we show that delta-like ligand 4 (Dll4) was upregulated on dendritic cells in response to cockroach allergen. Blocking Dll4 in vivo during either the primary or secondary response enhanced allergen-induced pathogenic consequences including airway hyperresponsiveness and mucus… CONTINUE READING

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