Notch inhibitors for cancer treatment.

  title={Notch inhibitors for cancer treatment.},
  author={Ingrid Espinoza and Lucio Miele},
  journal={Pharmacology & therapeutics},
  volume={139 2},
Notch signaling is an evolutionarily conserved cell signaling pathway involved in cell fate during development, stem cell renewal and differentiation in postnatal tissues. Roles for Notch in carcinogenesis, in the biology of cancer stem cells and tumor angiogenesis have been reported. These features identify Notch as a potential therapeutic target in oncology. Based on the molecular structure of Notch receptor, Notch ligands and Notch activators, a set of Notch pathway inhibitors have been… CONTINUE READING

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