Notch inhibition allows oncogene independent generation of iPS cells

  title={Notch inhibition allows oncogene independent generation of iPS cells},
  author={Justin K. Ichida and Julia TCW and Luis A. Williams and Ava C. Carter and Yingxiao Shi and Marcelo T. Moura and Michael J. Ziller and Sean Singh and Giovanni Amabile and Christoph Bock and Akihiro Umezawa and Lee L Rubin and James E. Bradner and Hidenori Akutsu and Alexander Meissner and Kevin C. Eggan},
  booktitle={Nature chemical biology},
The reprogramming of somatic cells to pluripotency using defined transcription factors holds great promise for biomedicine. However, human reprogramming remains inefficient and relies either on the use of the potentially dangerous oncogenes KLF4 and CMYC or the genetic inhibition of the tumor suppressor gene p53. We hypothesized that inhibition of signal transduction pathways that promote differentiation of the target somatic cells during development might relieve the requirement for non-core… CONTINUE READING
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