Notch-induced T cell development requires phosphoinositide-dependent kinase 1

@inproceedings{Kelly2007NotchinducedTC,
  title={Notch-induced T cell development requires phosphoinositide-dependent kinase 1},
  author={April P. Kelly and David K Finlay and Heather J. Hinton and Rosie G Clarke and Emma Fiorini and Freddy Radtke and Doreen A Cantrell},
  booktitle={The EMBO journal},
  year={2007}
}
Phosphoinositide-dependent kinase l (PDK1) phosphorylates and activates multiple AGC serine kinases, including protein kinase B (PKB), p70Ribosomal S6 kinase (S6K) and p90Ribosomal S6 kinase (RSK). PDK1 is required for thymocyte differentiation and proliferation, and herein, we explore the molecular basis for these essential functions of PDK1 in T lymphocyte development. A key finding is that PDK1 is required for the expression of key nutrient receptors in T cell progenitors: CD71 the… CONTINUE READING