Notch-independent functions of CSL.

  title={Notch-independent functions of CSL.},
  author={Jane E Johnson and Raymond J MacDonald},
  journal={Current topics in developmental biology},
Notch-dependent CSL transcription complexes control essential biological processes such as cell proliferation, differentiation, and cell-fate decisions in diverse developmental systems. The orthologous proteins CBF1/Rbpj (mammalian), Su(H) (Drosophila), and Lag-1 (Caenorhabditis elegans) compose the CSL family of sequence-specific DNA-binding transcription factors. The CSL proteins are best known for their role in canonical Notch signaling. However, CSL factors also form transcription complexes… CONTINUE READING

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