Notch in the development of thyroid C-cells and the treatment of medullary thyroid cancer.

@article{Cook2010NotchIT,
  title={Notch in the development of thyroid C-cells and the treatment of medullary thyroid cancer.},
  author={Mackenzie R. Cook and Xiao-min Yu and Herbert C Chen},
  journal={American journal of translational research},
  year={2010},
  volume={2 1},
  pages={119-25}
}
The Notch pathway plays an important role in the normal development of neuroendocrine cells, including the calcitonin producing C-cells of the thyroid. This effect has been elucidated to be mediated through modulation of Achaete-Scute Complex Like 1 (ASCL1), a transcription factor associated with poor prognosis in neuroendocrine cancer. Medullary thyroid… CONTINUE READING