Notch in fibrosis and as a target of anti-fibrotic therapy.

  title={Notch in fibrosis and as a target of anti-fibrotic therapy.},
  author={Biao Hu and Sem H. Phan},
  journal={Pharmacological research},
The Notch pathway represents a highly conserved signaling network with essential roles in regulation of key cellular processes and functions, many of which are critical for development. Accumulating evidence indicates that it is also essential for fibrosis and thus the pathogenesis of chronic fibroproliferative diseases in diverse organs and tissues. Different effects of Notch activation are observed depending on cellular and tissue context as well as in both physiologic and pathologic states… CONTINUE READING
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