Notch-effector CSL promotes squamous cell carcinoma by repressing histone demethylase KDM6B.

Abstract

Notch 1/2 genes play tumor-suppressing functions in squamous cell carcinoma (SCC), a very common malignancy in skin and internal organs. In contrast with Notch, we show that the transcription factor CSL (also known as RBP-Jκ), a key effector of canonical Notch signaling endowed with intrinsic transcription-repressive functions, plays a tumor-promoting… (More)
DOI: 10.1172/JCI96915