Notch-dependent EMT is attenuated in patients with aortic aneurysm and bicuspid aortic valve.

@article{Kostina2016NotchdependentEI,
  title={Notch-dependent EMT is attenuated in patients with aortic aneurysm and bicuspid aortic valve.},
  author={Aleksandra Kostina and Vladimir Uspensky and Olga Irtyuga and Elena V Ignatieva and Olga Freylikhman and Natalia Dmitrievna Gavriliuk and Olga Mikhailovna Moiseeva and Sergey Zhuk and Alexey N. Tomilin and Аnna А Kostareva and Anna B Malashicheva},
  journal={Biochimica et biophysica acta},
  year={2016},
  volume={1862 4},
  pages={
          733-740
        }
}
Bicuspid aortic valve is the most common congenital heart malformation and the reasons for the aortopathies associated with bicuspid aortic valve remain unclear. NOTCH1 mutations are associated with bicuspid aortic valve and have been found in individuals with various left ventricular outflow tract abnormalities. Notch is a key signaling during cardiac valve formation that promotes the endothelial-to-mesenchymal transition. We address the role of Notch signaling in human aortic endothelial… CONTINUE READING

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