Notch and Wnt Signaling Mediated Rod Photoreceptor Regeneration by Müller Cells in Adult Mammalian Retina

  title={Notch and Wnt Signaling Mediated Rod Photoreceptor Regeneration by M{\"u}ller Cells in Adult Mammalian Retina},
  author={Carolina Beltrame Del Debbio and Sudha Balasubramanian and Sowmya Parameswaran and Anathbandhu Chaudhuri and Fang Qiu and Iqbal Ahmad},
  booktitle={PloS one},
BACKGROUND Evidence emerging from a variety of approaches used in different species suggests that Müller cell function may extend beyond its role of maintaining retinal homeostasis to that of progenitors in the adult retina. Enriched Müller cells in vitro or those that re-enter cell cycle in response to neurotoxin-damage to retina in vivo display multipotential and self-renewing capacities, the cardinal features of stem cells. METHODOLOGY/PRINCIPAL FINDINGS We demonstrate that Notch and Wnt… CONTINUE READING


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