Notch and NF-kB signaling pathways regulate miR-223/FBXW7 axis in T-cell acute lymphoblastic leukemia

@article{Kumar2014NotchAN,
  title={Notch and NF-kB signaling pathways regulate miR-223/FBXW7 axis in T-cell acute lymphoblastic leukemia},
  author={Vijay Kumar and Rocco Palermo and Claudio Talora and Antonio Francesco Campese and Saula Checquolo and Diana Bellavia and L Tottone and Giuseppe Testa and Evelina Miele and Stefano Indraccolo and Alberto Amadori and Elisabetta Ferretti and Alberto Gulino and Alessandra Vacca and Isabella Screpanti},
  journal={Leukemia},
  year={2014},
  volume={28},
  pages={2324-2335}
}
Notch signaling deregulation is linked to the onset of several tumors including T-cell acute lymphoblastic leukemia (T-ALL). Deregulated microRNA (miRNA) expression is also associated with several cancers, including leukemias. However, the transcriptional regulators of miRNAs, as well as the relationships between Notch signaling and miRNA deregulation, are poorly understood. To identify miRNAs regulated by Notch pathway, we performed microarray-based miRNA profiling of several Notch-expressing… CONTINUE READING

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