Notch activity synergizes with B-cell-receptor and CD40 signaling to enhance B-cell activation.

@article{Thomas2007NotchAS,
  title={Notch activity synergizes with B-cell-receptor and CD40 signaling to enhance B-cell activation.},
  author={Matthew D Thomas and Marco Calamito and Bhaskar Srivastava and Ivan P Maillard and Warren S Pear and David Allman},
  journal={Blood},
  year={2007},
  volume={109 8},
  pages={3342-50}
}
How diverse environmental cues are integrated to regulate B-cell activation and development remains poorly understood. Here we show that Notch activity synergizes with B-cell receptor (BCR) and/or CD40 signaling to enhance several aspects of B-cell activation and function. We find that costimulation of follicular B cells with the Notch ligand Delta-like-1 leads to significant increases in BCR- and CD40-mediated proliferation and enhances production of IgG1(+) cells in vitro and in vivo. We… CONTINUE READING

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