Notch activation is an early and critical event during T-Cell leukemogenesis in Ikaros-deficient mice.

@article{Dumortier2006NotchAI,
  title={Notch activation is an early and critical event during T-Cell leukemogenesis in Ikaros-deficient mice.},
  author={Alexis Dumortier and Robin Jeannet and Peggy Kirstetter and Eva Kleinmann and Maclean C Sellars and Nuno R. dos Santos and Christelle Thibault and Jochen Barths and Jacques Ghysdael and Jennifer A Punt and Philippe Kastner and Susan Lai Chan},
  journal={Molecular and cellular biology},
  year={2006},
  volume={26 1},
  pages={
          209-20
        }
}
The Ikaros transcription factor is both a key regulator of lymphocyte differentiation and a tumor suppressor in T lymphocytes. Mice carrying a hypomorphic mutation (Ik(L/L)) in the Ikaros gene all develop thymic lymphomas. Ik(L/L) tumors always exhibit strong activation of the Notch pathway, which is required for tumor cell proliferation in vitro. Notch activation occurs early in tumorigenesis and may precede transformation, as ectopic expression of the Notch targets Hes-1 and Deltex-1 is… CONTINUE READING
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