Notch Signaling and the Skeleton.

  title={Notch Signaling and the Skeleton.},
  author={Stefano Zanotti and Ernesto Canalis},
  journal={Endocrine reviews},
  volume={37 3},
Notch 1 to 4 receptors are important determinants of cell fate and function, and Notch signaling plays an important role in skeletal development and bone remodeling. After direct interactions with ligands of the Jagged and Delta-like families, a series of cleavages release the Notch intracellular domain (NICD), which translocates to the nucleus where it induces transcription of Notch target genes. Classic gene targets of Notch are hairy and enhancer of split (Hes) and Hes-related with YRPW… CONTINUE READING


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