Notch Signaling Regulates the Lifespan of Vascular Endothelial Cells via a p16-Dependent Pathway

Evolutionarily conserved Notch signaling controls cell fate determination and differentiation during development, and is also essential for neovascularization in adults. Although recent studies suggest that the Notch pathway is associated with age-related conditions, it remains unclear whether Notch signaling is involved in vascular aging. Here we show that… (More)