Notch Signaling Components

  title={Notch Signaling Components},
  author={Zhiyan Liu and Tao Wu and Qing Li and Mincong Wang and Li Jing and Zhiping Ruan and Yu Yao and Kejun Nan and Hui Guo},
Abstract Non-small-cell lung cancer (NSCLC) is a lethal and aggressive malignancy. Currently, the identities of prognostic and predictive makers of NSCLC have not been fully established. Dysregulated Notch signaling has been implicated in many human malignancies, including NSCLC. However, the prognostic value of measuring Notch signaling and the utility of developing Notch-targeted therapies in NSCLC remain inconclusive. The present study investigated the association of individual Notch… 
Expression of Notch Gene and Its Impact on Survival of Patients with Resectable Non-small Cell Lung Cancer
Both higher Notch1 and Notch3 expression was associated with poor prognosis in lung adenocarcinoma and the expression of Notch gene had no impact on overall survival.
NOTCH3 is a Prognostic Factor and Is Correlated With Immune Tolerance in Gastric Cancer
A new mechanism by which Notch3 participates in the immune tolerance of GC is uncovered, implying the potential of NOTCH3 as a therapeutic target or predictive marker for GC patients.
Prevalence of Delta-Like Protein 3 in a Consecutive Series of Surgically Resected Lung Neuroendocrine Neoplasms
The results suggest that the DLL3 expression could identify a subset of AC tumors with more aggressive behavior, thus providing the basis for new therapeutic options in this group of patients, and confirm that D LL3 could represent a useful biomarker for target therapy in high-grade tumors.
Upregulated delta-like protein 3 expression is a diagnostic and prognostic marker in endometrial cancer
The multivariate analysis showed that DLL3 overexpression and advanced tumor stages, grades, and lymph node metastases were all independent prognostic predictors for endometrial cancer.
Ubiquitination of NOTCH2 by DTX3 suppresses the proliferation and migration of human esophageal carcinoma
This study suggested that the DTX3‐NOTCH2 axis plays an important role in the progression of esophageal cancer, andDTX3 acts as an anti–oncogene in esophagal carcinoma, potentially offering a therapeutic target for esophAGEal cancer.
High expression of C-X-C chemokine receptor 4 and Notch1 is predictive of lymphovascular invasion and poor prognosis in lung adenocarcinoma
  • Z. Cong, Hai-wei Wu, Yi Shen
  • Medicine, Biology
    Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine
  • 2017
Co-expression of C-X-C chemokine receptor 4 and Notch1 is associated with tumor progression and lymphovascular invasion and is an independent indicator of poor survival in lung adenocarcinoma.
Anti-Jagged-1 immunotherapy in cancer.
Notch Transduction in Non-Small Cell Lung Cancer
This review focuses on the role this intercellular signaling device plays during lung development and on its functional relevance in proximo-distal cell fate specification, branching morphogenesis, and alveolar cell determination and maturation, and revise its involvement in NSCLC formation, progression and treatment refractoriness.
The Role of DLLs in Cancer: A Novel Therapeutic Target
The role of DLLs in cancer is discussed, the emerging DLL-relevant targeting methods to aid future studies are summarized and the current state-of-the-art targeting methods are summarized.


Notch3 overexpression associates with poor prognosis in human non-small-cell lung cancer
Notch3 had high expression in 67 of 131 cases of NSCLC and was significantly higher than in adjacent noncancerous lung tissues, and Kaplan–Meier survival analysis showed that the overall survival times in patients expressing Notch3 inNSCLC were shorter.
Meta-analysis reveals the correlation of Notch signaling with non-small cell lung cancer progression and prognosis
It is indicated that higher expression of Notch1 was associated with greater possibility of lymph node metastasis and higher TNM stages and targeting Notch signaling could benefit subpopulation of NSCLC patients, and notch signaling is a valuable bio-marker to predict progression.
Notch signaling in lung cancer
Notch receptors’ activity can be blocked through the use of different strategies, thus representing a promising alternative/complement to the arsenal of therapeutic strategies currently used to treat lung cancer.
Coexpression of c-Met and Notch-1 correlates with poor prognosis in resected non-small-cell lung cancer
Coexpression of both receptors correlates with poorer prognosis in patients with resected NSCLC and targeting both receptors simultaneously may prove a more effective antitumor strategy.
Notch1 is required for Kras-induced lung adenocarcinoma and controls tumor cell survival via p53.
Findings implicate Notch1 as a critical effector in Kras-driven lung adenocarcinoma and as a regulator of p53 at a posttranslational level and provides new insights to explain the correlation between Notch 1 activity and poor prognosis in patients with NSCLC carrying wild-type p53.
Opposing role of Notch1 and Notch2 in a KrasG12D-driven murine non-small cell lung cancer model
This is the first study characterizing the in vivo functions of Notch1 and Notch2 in KrasG12D-driven NSCLC tumorigenesis, and shows that notch2 mediates differentiation and has tumor suppressor functions during lung carcinogenesis, whereas notch1 promotes tumor initiation and progression.
Notch1 ligand signaling pathway activated in cervical cancer: poor prognosis with high-level JAG1/Notch1
Investigating the significance and prognostic value of expression of Notch1 and JAG1 in cervical cancer proved the over-expression of notch1/JAGD1 and its association with tumor progression in human cervical cancer, which might be a potential valuable biomarker for cervical cancer and further studies need.
Differential effects of targeting Notch receptors in a mouse model of liver cancer
Findings underscore the distinct roles of different Notch receptors in the liver and suggest that inhibition of Notch2 signaling represents a novel therapeutic option in the treatment of liver cancer.
Expression of Notch-1 and its clinical significance in different histological subtypes of human lung adenocarcinoma
Notch-1 could be used as a predictable biomarker to be detected in different pathological and histological subtypes in LAD for diagnosis or prognosis.