Notch Signaling Components

@article{Liu2016NotchSC,
  title={Notch Signaling Components},
  author={Zhiyan Liu and Tao Wu and Qing Li and Mincong Wang and Li Jing and Zhiping Ruan and Yu Yao and Kejun Nan and Hui Guo},
  journal={Medicine},
  year={2016},
  volume={95}
}
Abstract Non-small-cell lung cancer (NSCLC) is a lethal and aggressive malignancy. Currently, the identities of prognostic and predictive makers of NSCLC have not been fully established. Dysregulated Notch signaling has been implicated in many human malignancies, including NSCLC. However, the prognostic value of measuring Notch signaling and the utility of developing Notch-targeted therapies in NSCLC remain inconclusive. The present study investigated the association of individual Notch… 
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12 Citations
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12 Citations

Expression of Notch Gene and Its Impact on Survival of Patients with Resectable Non-small Cell Lung Cancer
TLDR
Both higher Notch1 and Notch3 expression was associated with poor prognosis in lung adenocarcinoma and the expression of Notch gene had no impact on overall survival.
NOTCH3 is a Prognostic Factor and Is Correlated With Immune Tolerance in Gastric Cancer
TLDR
A new mechanism by which Notch3 participates in the immune tolerance of GC is uncovered, implying the potential of NOTCH3 as a therapeutic target or predictive marker for GC patients.
Prevalence of Delta-Like Protein 3 in a Consecutive Series of Surgically Resected Lung Neuroendocrine Neoplasms
TLDR
The results suggest that the DLL3 expression could identify a subset of AC tumors with more aggressive behavior, thus providing the basis for new therapeutic options in this group of patients, and confirm that D LL3 could represent a useful biomarker for target therapy in high-grade tumors.
Upregulated delta-like protein 3 expression is a diagnostic and prognostic marker in endometrial cancer
TLDR
The multivariate analysis showed that DLL3 overexpression and advanced tumor stages, grades, and lymph node metastases were all independent prognostic predictors for endometrial cancer.
Expression of delta-like protein 3 is reproducibly present in a subset of small cell lung carcinomas and pulmonary carcinoid tumors.
Ubiquitination of NOTCH2 by DTX3 suppresses the proliferation and migration of human esophageal carcinoma
TLDR
This study suggested that the DTX3‐NOTCH2 axis plays an important role in the progression of esophageal cancer, andDTX3 acts as an anti–oncogene in esophagal carcinoma, potentially offering a therapeutic target for esophAGEal cancer.
High expression of C-X-C chemokine receptor 4 and Notch1 is predictive of lymphovascular invasion and poor prognosis in lung adenocarcinoma
  • Z. Cong, Hai-wei Wu, Yi Shen
  • Medicine, Biology
    Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine
  • 2017
TLDR
Co-expression of C-X-C chemokine receptor 4 and Notch1 is associated with tumor progression and lymphovascular invasion and is an independent indicator of poor survival in lung adenocarcinoma.
Anti-Jagged-1 immunotherapy in cancer.
Notch Transduction in Non-Small Cell Lung Cancer
TLDR
This review focuses on the role this intercellular signaling device plays during lung development and on its functional relevance in proximo-distal cell fate specification, branching morphogenesis, and alveolar cell determination and maturation, and revise its involvement in NSCLC formation, progression and treatment refractoriness.
The Role of DLLs in Cancer: A Novel Therapeutic Target
TLDR
The role of DLLs in cancer is discussed, the emerging DLL-relevant targeting methods to aid future studies are summarized and the current state-of-the-art targeting methods are summarized.
...
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References

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TLDR
Notch3 had high expression in 67 of 131 cases of NSCLC and was significantly higher than in adjacent noncancerous lung tissues, and Kaplan–Meier survival analysis showed that the overall survival times in patients expressing Notch3 inNSCLC were shorter.
Meta-analysis reveals the correlation of Notch signaling with non-small cell lung cancer progression and prognosis
TLDR
It is indicated that higher expression of Notch1 was associated with greater possibility of lymph node metastasis and higher TNM stages and targeting Notch signaling could benefit subpopulation of NSCLC patients, and notch signaling is a valuable bio-marker to predict progression.
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TLDR
Notch receptors’ activity can be blocked through the use of different strategies, thus representing a promising alternative/complement to the arsenal of therapeutic strategies currently used to treat lung cancer.
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TLDR
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TLDR
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TLDR
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TLDR
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TLDR
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TLDR
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