Notch Post-Translationally Regulates β-Catenin Protein in Stem and Progenitor Cells

Abstract

Cellular decisions of self-renewal or differentiation arise from integration and reciprocal titration of numerous regulatory networks. Notch and Wnt/β-catenin signalling often intersect in stem and progenitor cells and regulate each other transcriptionally. The biological outcome of signalling through each pathway often depends on the context and timing as… (More)
DOI: 10.1038/ncb2313

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