Notch-Jagged signalling can give rise to clusters of cells exhibiting a hybrid epithelial/mesenchymal phenotype

@inproceedings{Boareto2016NotchJaggedSC,
  title={Notch-Jagged signalling can give rise to clusters of cells exhibiting a hybrid epithelial/mesenchymal phenotype},
  author={Marcelo Boareto and Mohit Kumar Jolly and Aaron Goldman and Mika Pietil{\"a} and Sendurai Mani and Shiladitya Sengupta and Eshel Ben-Jacob and Herbert Levine and Jos{\'e} N. Onuchic},
  booktitle={Journal of the Royal Society, Interface},
  year={2016}
}
Metastasis can involve repeated cycles of epithelial-to-mesenchymal transition (EMT) and its reverse mesenchymal-to-epithelial transition. Cells can also undergo partial transitions to attain a hybrid epithelial/mesenchymal (E/M) phenotype that allows the migration of adhering cells to form a cluster of circulating tumour cells. These clusters can be apoptosis-resistant and possess an increased metastatic propensity as compared to the cells that undergo a complete EMT (mesenchymal cells). Hence… CONTINUE READING
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