Notch 1 signaling is active in ovarian cancer.

@article{Rose2010Notch1S,
  title={Notch 1 signaling is active in ovarian cancer.},
  author={Stephen L. Rose and Muthusamy Kunnimalaiyaan and Jessica G. Drenzek and Nicole L. Seiler},
  journal={Gynecologic oncology},
  year={2010},
  volume={117 1},
  pages={
          130-3
        }
}
OBJECTIVE.: Despite advances in chemotherapy and radical surgery, most advanced stage ovarian cancer patients die from their disease, highlighting the need for the development of novel treatment strategies. The Notch signaling pathway plays an important role in cellular differentiation, proliferation and apoptosis. We hypothesized that the active form of Notch 1, the Notch 1 intracellular domain (NICD), would be overexpressed in ovarian cancer cells and that depletion of NICD would lead to… CONTINUE READING

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