Notch-1 regulates pulmonary neuroendocrine cell differentiation in cell lines and in transgenic mice.

@article{Shan2007Notch1RP,
  title={Notch-1 regulates pulmonary neuroendocrine cell differentiation in cell lines and in transgenic mice.},
  author={Lin Shan and Jon C Aster and Jeffrey Sklar and Mary E. Sunday},
  journal={American journal of physiology. Lung cellular and molecular physiology},
  year={2007},
  volume={292 2},
  pages={L500-9}
}
The notch gene family encodes transmembrane receptors that regulate cell differentiation by interacting with surface ligands on adjacent cells. Previously, we demonstrated that tumor necrosis factor-alpha (TNF) induces neuroendocrine (NE) cell differentiation in H82, but not H526, undifferentiated small cell lung carcinoma lines. We now test the hypothesis that TNF mediates NE cell differentiation in part by altering Notch gene expression. First, using RT-PCR, we determined that TNF treatment… CONTINUE READING