Notch-1 regulates Akt signaling pathway and the expression of cell cycle regulatory proteins cyclin D1, CDK2 and p21 in T-ALL cell lines.

@article{Guo2009Notch1RA,
  title={Notch-1 regulates Akt signaling pathway and the expression of cell cycle regulatory proteins cyclin D1, CDK2 and p21 in T-ALL cell lines.},
  author={Dongmei Guo and Jingjing Ye and Jianjian Dai and Lizhen Li and F. -X. Chen and Dao-xin Ma and Chunyan Ji},
  journal={Leukemia research},
  year={2009},
  volume={33 5},
  pages={678-85}
}
Gain-of-function mutations in Notch-1 are common in T-cell lymphoblastic leukemia (T-ALL), making this receptor a promising target for drugs such as gamma-secretase inhibitors (GSIs). However, GSIs seem to be active in only a small fraction of T-ALL cell lines with constitutive Notch-1 activity and the downstream response of Notch signaling is only… CONTINUE READING