Notch–RBP-J signaling is involved in cell fate determination of marginal zone B cells

@article{Tanigaki2002NotchRBPJSI,
  title={Notch–RBP-J signaling is involved in cell fate determination of marginal zone B cells},
  author={Kenji Tanigaki and Hua Han and Norio Yamamoto and K. Tashiro and Masaya Ikegawa and Kazuki Kuroda and Akira Suzuki and Toru Nakano and T. Honjo},
  journal={Nature Immunology},
  year={2002},
  volume={3},
  pages={443-450}
}
RBP-J is a key mediator of Notch signaling that regulates cell fate determination in various lineages. To investigate the function of Notch–RBP-J in mature B cell differentiation, we generated mice that selectively lacked B cell RBP-J expression using conditional mutagenesis. Absence of RBP-J led to the loss of marginal zone B (MZB) cells with a concomitant increase in follicular B cells; in contrast, B1 cells in the peritoneal cavity were unaffected. Lack of RBP-J caused no defects in B cells… CONTINUE READING
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similarities and differences with other B cell subsets

  • F. Martin, Kearney, J. F. B1 cells
  • Curr. Opin. Immunol. 13, 195–201
  • 2001

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