Not your regular high: cardiac dysrhythmias caused by loperamide.

  title={Not your regular high: cardiac dysrhythmias caused by loperamide.},
  author={Rachel Sarah Wightman and Robert S Hoffman and Mary Ann Howland and Brian Travis Rice and Rana Biary and Daniel M. Lugassy},
  journal={Clinical toxicology},
  volume={54 5},
OBJECTIVE Loperamide, a non-prescription anti-diarrheal agent, is a peripheral mu-opioid receptor agonist that is excluded from the blood-brain barrier by p-glycoprotein at therapeutic doses. Overdoses of loperamide penetrate the central nervous system (CNS), leading to abuse. We report cardiac conduction abnormalities and dysrhythmias after ingestion of a… CONTINUE READING
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