Not lipoteichoic acid but lipoproteins appear to be the dominant immunobiologically active compounds in Staphylococcus aureus.

@article{Hashimoto2006NotLA,
  title={Not lipoteichoic acid but lipoproteins appear to be the dominant immunobiologically active compounds in Staphylococcus aureus.},
  author={Masahito Hashimoto and Kazuki Tawaratsumida and Hiroyuki Kariya and Ai Kiyohara and Yasuo Suda and Fumiko Krikae and Teruo Kirikae and Friedrich G{\"o}tz},
  journal={Journal of immunology},
  year={2006},
  volume={177 5},
  pages={3162-9}
}
Lipoteichoic acid (LTA) derived from Staphylococcus aureus is reported to be a ligand of TLR2. However, we previously demonstrated that LTA fraction prepared from bacterial cells contains lipoproteins, which activate cells via TLR2. In this study, we investigated the immunobiological activity of LTA fraction obtained from S. aureus wild-type strain, lipoprotein diacylglycerol transferase deletion (delta lgt) mutant, which lacks palmitate-labeled lipoproteins, and its complemented strain and… CONTINUE READING

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