Not all statins interfere with clopidogrel during antiplatelet therapy.

@article{Mach2005NotAS,
  title={Not all statins interfere with clopidogrel during antiplatelet therapy.},
  author={François Mach and David Senouf and Pierre Fontana and Françoise Boehlen and Guido Reber and Youssef Daali and Philippe de Moerloose and Ulrich Sigwart},
  journal={European journal of clinical investigation},
  year={2005},
  volume={35 8},
  pages={476-81}
}
BACKGROUND Clopidogrel and statins are frequently coadministered in patients with ischemic heart diseases. Recent reports suggested that clopidogrel's effectiveness in inhibiting adenosine diphosphate (ADP)-induced platelets aggregation is attenuated by co-administration of certain statins. The objective of the present study was to define which statin might interfere with the antiaggregation property of clopidogrel. METHODS We designed a pharmacokinetic study and tested ex vivo platelet… CONTINUE READING