Not all HLA DR3 DQ2 haplotypes confer equal susceptibility to coeliac disease: transmission analysis in families.

@article{Karell2002NotAH,
  title={Not all HLA DR3 DQ2 haplotypes confer equal susceptibility to coeliac disease: transmission analysis in families.},
  author={Kati Karell and P{\"a}ivi M. Holopainen and Kirsi Mustalahti and Pekka Collin and Markku J M{\"a}ki and Jukka Partanen},
  journal={Scandinavian journal of gastroenterology},
  year={2002},
  volume={37 1},
  pages={56-61}
}
BACKGROUND HLA-DQ is the only established susceptibility factor for coeliac disease. We tested whether all HLA haplotypes with the known risk marker, HLA-DQ2, confer equal susceptibility to coeliac disease, i.e. whether haplotype transmission from DQ2 homozygous parents to patients is random. The random transmission would strengthen the importance of DQ2 as the only risk factor within the HLA region. METHODS Inheritance of DQ2-positive haplotypes from parent to patients was investigated in 14… CONTINUE READING