Not Just a Plasma Membrane Protein: in Cardiac Muscle Cells Alpha-II Spectrin also Shows a Close Association with Myofibrils

@article{Bennett2004NotJA,
  title={Not Just a Plasma Membrane Protein: in Cardiac Muscle Cells Alpha-II Spectrin also Shows a Close Association with Myofibrils},
  author={Pauline M Bennett and Anthony J. Baines and M H Lecomte and Alison M. Maggs and Jennifer Pinder},
  journal={Journal of Muscle Research & Cell Motility},
  year={2004},
  volume={25},
  pages={119-126}
}
Spectrin and its associated proteins are essential for the integrity of muscle cells and there is increasing evidence for their involvement in signalling pathways as well as having a structural function in mediating stress. Spectrin is a multigene family and it is essential to determine which isoforms are present and their location in the cell. In heart muscle, we have found that one spectrin isoform, αII-spectrin, is strongly represented and, using immunofluorescence, we show that it lies… CONTINUE READING

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