Nosocomial pneumonia in intubated patients given sucralfate as compared with antacids or histamine type 2 blockers. The role of gastric colonization.

@article{Driks1987NosocomialPI,
  title={Nosocomial pneumonia in intubated patients given sucralfate as compared with antacids or histamine type 2 blockers. The role of gastric colonization.},
  author={Michael R. Driks and Donald E. Craven and Bartolome R Celli and Martina Manning and Roger A. Burke and Johnny Lee Jackson and Laureen M. Kunches and Harrison W. Farber and Susanne Wedel and William R. Mccabe},
  journal={The New England journal of medicine},
  year={1987},
  volume={317 22},
  pages={
          1376-82
        }
}
Gram-negative nosocomial pneumonia may result from retrograde colonization of the pharynx from the stomach, and this may be more likely when the gastric pH is relatively high. We studied the rate of nosocomial pneumonia among 130 patients given mechanical ventilation in an intensive care unit who were receiving as prophylaxis for stress ulcer either sucralfate (n = 61), which does not raise gastric pH, or conventional treatment with antacids, histamine type 2 (H2) blockers, or both (n = 69). At… CONTINUE READING
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Nosocomial pneumonia in the intubated patient: Role of gastric colonization

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