Nosing in on the emotional brain

Abstract

The EphA4 ephrin receptor (labeled in red) is enriched on dendritic spines of pyramidal neurons in the adult mouse hippocampus. Its ligand, ephrin-A3, is localized to adjacent astrocytes. Pasquale et al. show that neuroglial cross-talk via this ligand–receptor signaling system can regulate spine morphology. The authors used mice expressing yellow… (More)
DOI: 10.1038/nn0203-106

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