Noscapine, a Non-addictive Opioid and Microtubule-Inhibitor in Potential Treatment of Glioblastoma

@article{Altinoz2019NoscapineAN,
  title={Noscapine, a Non-addictive Opioid and Microtubule-Inhibitor in Potential Treatment of Glioblastoma},
  author={M. Altinoz and G. Topc̡u and A. Hacimuftuoglu and A. Ozpinar and Emily Hacker and I. Elmaci},
  journal={Neurochemical Research},
  year={2019},
  volume={44},
  pages={1796 - 1806}
}
Noscapine is a phthalide isoquinoline alkaloid that easily traverses the blood brain barrier and has been used for years as an antitussive agent with high safety. Despite binding opioid receptors, noscapine lacks significant hypnotic and euphoric effects rendering it safe in terms of addictive potential. In 1954, Hans Lettré first described noscapine as a mitotic poison. The drug was later tested for cancer treatment in the early 1960's, yet no effect was observed likely as a result of its… Expand

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